For that reason, it can be conceivable which the JIP1/3???ASK1???MKK4 signaling module may serve as a conduit to activate JNK when endosomal trafficking is disrupted and glucose concentrations fall through the early stages of methuosis. Our obtaining that MKK4 was robustly activated because of the methuosis-inducing IPPs, MOMIPP and 2q, and less so